| 摘要: |
| 随着人口老龄化问题的凸显，衰老相关的研究越来越被重视。秀丽隐杆线虫（Caenorhabditis elegans）是抗衰老研究领域中非常重要的生物模型，具有生命周期短、易于培养和观察等优点，但与其他哺乳动物模型相比仍有一些局限性，如DNA甲基化的缺乏等。本文主要综述了秀丽隐杆线虫模型在抗衰老研究和药物筛选中的应用，包括抗衰老药物对线虫寿命和抗性的测定与评估、药物筛选以及健康衰老研究中的应用，并概括了该模型的优势和局限性，为秀丽隐杆线虫模型在抗衰老研究中的应用提供理论依据。 |
| 关键词: 秀丽隐杆线虫 抗衰老 基因 应用 |
| DOI：10.14188/j.ajsh.2023.01.002 |
| 分类号:R383.1 |
| 基金项目:山东省自然科学基金（ZR2021LSW022；ZR2021QB173；ZR2022QC186）；山东省“泰山青年学者”计划（tsqn202103100）；济南市“新高校20条”资助项目（2021GXRC062）；高端外国专家引进计划（G2021023002L）；齐鲁工业大学（山东省科学院）科教产融合创新试点工程项目（2022GH024） |
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| Application of Caenorhabditis elegans model in anti-aging research |
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MENG Yiwei1, ZHAO Yanqiu1, MENG Qingzhou1, WU Qinghua1, QU Kunyu1, ZHAO Peipei1, WANG Mengmeng1, ZHAO Xiangxiang1, DAI Huanqin2, YIN Xin1, XIA Xuekui1
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1.Biology Institute， Qilu University of Technology （Shandong Academy of Sciences）， Jinan 250103， Shandong， China;2.State Key Laboratory of Mycology， Institute of Microbiology， Chinese Academy of Sciences， Beijing 100101， China
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| Abstract: |
| With the aging of population， more and more attention has been paid to the research on aging. Caenorhabditis elegans is a very important biological model in the field of anti-aging research. It has the advantages of short life cycle， easy cultivation and observation， but it still has some limitations compared with other mammalian models， such as the lack of DNA methylation. This paper mainly reviews the application of the model of C. elegans in anti-aging research and drug screening， including the measurement and evaluation of anti-aging drugs against nematode longevity and resistance， drug screening， and the application of healthy aging research， and summarizes the advantages and limitations of the model. This paper provides a theoretical basis for the application of C. elegans model in anti-aging research. |
| Key words: Caenorhabditis elegans anti-aging gene application |
