| 摘要: |
| 南海海域广阔，生物资源丰富多样，其中微生物资源尚未得到全面系统的研究和挖掘。本文回顾了中山大学25年来在南海微生物资源及其活性代谢产物方面的研究成果，着重介绍了近10年来本校团队研究红树林真菌资源并对其次生代谢产物开展靶向抗结核、抗炎、抗Ⅱ型糖尿病和抗肿瘤筛选的进展。最后介绍近年来我们利用中山大学海洋科考计划在西沙群岛及其海域初步开展的微生物资源的研究。 |
| 关键词: 海洋微生物 红树林内生真菌 活性次级代谢产物 |
| DOI：10.14188/j.ajsh.2020.05.004 |
| 分类号:R931.77 |
| 基金项目:广东省自然资源厅-广东省促进经济高质量发展专项资金-海洋经济发展项目（GDOE[2019]A 35号） |
|
| Review on the research of marine fungus resources and their bioactive secondary metabolites from the South China Sea |
|
WANG Qinglin1,2, CHEN Shuihao3, CHEN Dongni1,2,3, LIU Lan2,3, SHE Zhigang2,4, LU Yongjun1,2
|
|
1.School of Life Sciences， Sun Yat-sen University， Guangzhou 510275， Guangdong， China;2.Biomedical Center， Sun Yat-sen University， Guangzhou 510275， Guangdong， China;3.School of Marine Sciences， Sun Yat-sen University， Zhuhai 519082， Guangdong， China;4.School of Chemistry， Sun Yat-sen University， Guangzhou 510275， Guangdong， China
|
| Abstract: |
| The South China Sea is vast and rich in biological resources， of which microbial resources have not been comprehensively studied and excavated. This article reviews the achievement of the microbial resources from the South China Sea and the screening for the active secondary metabolites in the past 25 years by Sun Yat-sen University， focusing on our research progress in mangrove endophytic fungi and their active metabolites over the past decade， including the screening of anti-inflammatory， anti-type 2 diabetes， anti-tumor， and anti-tuberculosis. Finally， our current research of microbial resources in Xisha islands and its sea area susing the marine scientific research plan of Sun Yat-sen University in recent years is introduced. |
| Key words: marine microorganism mangrove endophytic fungus bioactive secondary metabolite |
