| 摘要: |
| 肌肉生成抑制素（myostatin， MSTN）在动物机体骨骼肌的增殖、分化和生长中起着重要的负调控作用。MSTN基因的过表达会阻碍骨骼肌增殖分化及生长发育，而缺失或表达降低则会导致肌肉肥大，形成双肌现象（double muscle phenomenon， DMP）。MSTN能作用于多个基因及结合多种细胞因子广泛参与生理生化、物质代谢、病理调控等过程，在动物机体生长发育过程中扮演着重要的角色。本文将从MSTN基因的历史渊源、基因定位、时空表达特性、部分相关作用机制等方面进行论述，旨在对MSTN调控动物骨骼肌生长部分机制作梳理，以期为后期研究提供理论依据。 |
| 关键词: 骨骼肌 肌肉生成抑制素 生长发育 作用机制 |
| DOI：10.14188/j.ajsh.2019.06.002 |
| 分类号:S814.8 |
| 基金项目:国家科技重大专项（2014ZX0801012B; 2018ZX08010-08B）、广东省重点领域研发计划(2018B020203003)、佛山市科技创新项目计划(2017AG100111)和广东省动物分子设计与精准育种重点实验室开放课题(2018A05) |
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| Advances in regulatory mechanism of myostatin on animal skeletal muscle growth |
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TANG Dongsheng1,ZHAN Qunmei1,WEI Yanyan1,ZHU Xiangxing1
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Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding/Guangdong Provincial Research Center of Gene Editing Engineering Technology, Foshan University, Foshan,528225, Guangdong, China
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| Abstract: |
| Myostatin (MSTN) is a negative regulation factor of skeletal muscle growth and development in animals.Overexpression of MSTN gene will hinder the proliferation, differentiation, growth and development of skeletal muscle, while lack or reduced expression of MSTN gene will lead to muscle hypertrophy and the formation of double muscle phenomenon(DMP).MSTN can play an important role in the growth and development of animals by acting on multiple genes and combining with a variety of cytokines to participate in physiological, biochemical, material metabolism, pathological regulation and other processes.This review discusses the historical origin of MSTN gene, gene localization, spatio-temporal expression characteristics, and some relevant mechanisms, aiming to sort out some mechanisms of MSTN regulating skeletal muscle growth in animals, so as to provide theoretical basis for later research. |
| Key words: skeletal muscle myostatin growth and development action mechanism |
