| 摘要: |
| 目前，为应对抗生素耐药性问题，需要探索更多的抗生素替代物用于对抗微生物的感染。乳铁蛋白是一类源自哺乳动物乳汁或其他粘膜分泌的一种糖基化蛋白，具有广谱抗微生物活性、免疫调节以及抗癌作用。乳铁蛋白对于易受感染的早产儿也有很好的耐受作用，基本无不良反应，具有良好的开发前景。本文主要概述乳铁蛋白的基本性质、多功能的生物学活性和作用机制，并探讨牛乳铁蛋白与talactoferrin的临床研究情况。 |
| 关键词: 乳铁蛋白 多功能活性 牛乳铁蛋白 talactoferrin 临床应用 |
| DOI：10.14188/j.ajsh.2018.06.007 |
| 分类号:TS252.1 |
| 基金项目:江苏高校优势学科建设资助项目（PAPD） |
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KANG Xinyue,LIU Shicai,ZHENG Heng
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School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, Jiangsu, China
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| Abstract: |
| To deal with the problem of antibiotic resistance, it is necessary to explore more antibiotic substitutes to fight microbial infections. Lactoferrin is a type of glycosylated protein that is derived from mammalian milk or other mucosal secretions, and has a broad spectrum of antimicrobial activity, immunomodulation, and anti-cancer effects. During the use of lactoferrin, it is well tolerated in vulnerable low-birth-weight neonates and no adverse reactions. Hence, lactoferrin has a good prospects of development. This review summarizes the profile of lactoferrin and lactoferrin-derived peptide, and focuses on the clinical research of bovine lactoferrin and talactoferrin. |
| Key words: lactoferrin multifunctional activity bovine lactoferrin talactoferrin clinical application |
