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| DR-70TM和CA50肺癌免疫测定的应用价值 |
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闵磊1,2,曹军卫1,2,乔治1,3,许平4
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1. 武汉大学生命科学学院,武汉,430072;武汉大学基础医学院,武汉,430072;2. 武汉大学生命科学学院,武汉,430072;3. 武汉大学基础医学院,武汉,430072;4. 武汉钢铁集团公司第二医院肿瘤科
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| 摘要: |
| 目的:评价DR-70TM和CA50两种肿瘤标志物在肺癌检测中的价值.方法:应用DR-70TMELISA和CA50 IRMA对77例肺癌患者,42例健康者及48例其它肺癌者进行对照检测.结果:各组DR-70TMCA50测定值比例显示肺癌组平均值显著其它两组(P＜0.01).DR-70TM检测的敏感性和有效性高于CA50检测(83.1%比66.2%,85.7%比75.6%).两项联合检测的敏感性,有效性分别为96.1%,93.1%,优于单项DR-70TM检测的83.1%,85.7%,及CA50的66.29%、75.6%.结论:DR-70TM在肺癌检测中有较大应用价值.DR-70TM和CA50两项联合检测是较理想的肺癌检测组合. |
| 关键词: DR-70TM 肿瘤标志物 酶联免疫吸附试验 肺癌 |
| DOI： |
| 分类号:R730 |
| 基金项目: |
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| Application of DR-70TM and CA50 Immunoassay for Lung Cancer |
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| Abstract: |
| A study using DR-70 TM ELISA and CA50 IRMA to detect lung cancer in 77 patients with lung cancer, 42 healthy subjects and 48 patients with other lung diseases has been carried out. The level of two tumor markers in patients with lung cancer was higher than in patients with other lung diseases or in the healthy group (P<0.01). The sensitivity and validity of DR-70 TM were higher than those of CA50 (83.1% versus 66.2%, 85.7 versus 75.6%). The sensitivity and validity of combined DR-70 TM and CA50 were 96.1% 93.3% respectively. They were higher than those of the single tumor marker. DR-70 TM was of value in detecting lung cancer and combination of DR-70 TM and CA50 was a good at detecting lung cancer. |
| Key words: DR-70 TM tumor markers ELISA lung cancer |
