| 摘要: |
| 将新生Wistar大鼠按腹腔注射醋酸铅的剂量,随机分为正常、低铅组、高铅组.各组注射剂量分别为0,20,60 mg/kg.定期测量体重,采用薄板层析法测脑中精脒的含量.结果显示正常组出生后体重增长迅速;与正常组相比,高、低铅组分别于出生5、10天后体重增长明显落后;脑重、脑精脒含量均显著低于正常组,并且与铅损伤的剂量有明显的负相关(r=-0.793,P<0.01).研究表明脑中多胺的量是反映铅神经毒性程度的有用指标. |
| 关键词: 铅损伤 新生鼠 脑 精脒 |
| DOI： |
| 分类号:Q95.3 |
| 基金项目:江苏省社会发展基金 |
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| Influence of Pb on Polyamine Level in Neonatal Rat Brain |
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| Abstract: |
| Neonatal Wistar rats were divided into the control group, low Pb group and high Pb group, and Pb 3(AC) 2 at doses of 0,20,60 mg/kg and respectively. The weight was measured, and the spedimine level of the brain was determined with the thin-layer-chromatography. The growth of weight in the control group was rapid, but in Pb-exposed groups was slow. Compared with the control group, the growth of weight in the high and low Pb groups was significantly lower after postnatal 5,10 days; brain weight and brain Spedimine were all significantly decreased; and the spedimine level and Pb exposure dose had negative relativity (r=-0.793, p<0.01). The data showed that the polyamine of brain was an useful index for the degree of Pb impairment. |
| Key words: Pb neonatal rat brain spedimine |
