| 摘要: |
| 探讨IL-4对Lewis肺癌生长和转移的抑制作用. 将Lewis肺癌细胞接种于C57BL/6小鼠皮下.将20只小鼠随机分为两组,接种后第5天起分别给予生理盐水或IL-4.第18天处死动物,测两组肿瘤的平均体积,平均瘤重及肺转移灶.Ⅰ、Ⅱ组肿瘤的平均体积为(2.007±0.006)cm3,(0.404±0.010)cm3;平均瘤重为(2.833±0.074)g、(0.586±0.040)g,肺转移灶为(5.500±0.926),(3.375±1.061).Ⅱ组与I组比差异有显著性(P<0.05);平均潜伏期为:8.30±0.49;10.56±0.36.IL-4能抑制Lewis肺癌生长和转移. |
| 关键词: 肺肿瘤 IL-4 肿瘤转移 |
| DOI： |
| 分类号:R734.2 |
| 基金项目:湖北省自然科学基金，湖北省科技厅科研项目 |
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| An experimental study on Inhibition of IL-4 on growth and metastasis of Lewis lung carcinoma |
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| Abstract: |
| To investigate the inhibiting effects of IL-4 on Leuis lung cancer (LLC). Twenty mice trans planted with LLC Cells were randomized into two groups. From the 5th day, physiological saline and IL-4 were injected, respectively. On the 18th day, all the mice were killed. The volume,weight and lung metastasis counting of the tumors were detected. The tumor volume in group ⅠⅡ was (2.007±0.006)cm3, (0.404+0.010)cm3 respectively; the tumor weight of group ⅠⅡ was (2.833±0.074)g, (0.588±0.040)g, respectively. The lung metastais counting of group ⅠⅡ was 5.500±0.926,3.375±1.061, respectively.(P<0.05). |
| Key words: lung reoplasms IL-4 neoplasm metastasis |
