| 摘要: |
| β-烟酰胺单核苷酸（nicotinamide mononucleotide，NMN）是辅酶I——NAD+（nicotinamide adenine dinucleotide）合成的关键中间体，存在于各种生物体内。NAD+广泛参与体内多种反应，对人体健康起着非常重要的作用。服用烟酰胺单核苷酸后可以快速提升体内NAD+水平，从而在体内起到多种关键功能。近年来，研究NMN为年龄相关性功能衰退和疾病的发病机制提供了许多重要的见解。研究发现NMN具有多种功能作用，例如抗衰老，促进心脑健康等。NMN已经成为保健品、食品原料等领域研究的热点，其市场容量增长迅速，目前已有多种以NMN为主要成分的保健品上市销售。基于NMN持续火热的研究态势以及未来巨大的市场预期，本文较为系统地综述了NMN的研究背景、作用机理、保健功能、全球品牌产品、主要的化学方法与生物学方法的合成路线等，旨在为普及以及推动NMN在人类健康领域的研究和应用提供参考。 |
| 关键词: β-烟酰胺单核苷酸 烟酰胺磷酸核糖转移酶 烟酰胺核糖激酶 酶法合成 抗衰老 |
| DOI：10.14188/j.ajsh.2021.02.004 |
| 分类号:Q-1 |
| 基金项目:河北省高校应用技术研发中心平台项目（2020-4） |
|
| Research progress on function and synthesis of β-nicotinamide mononucleotide |
|
REN Limei, WANG Xiaoru, QI Yonghao, HAN Guangxin, HAN Tianmiao, GUI Yang, ZHANG Miao, LI Xiaobing
|
|
Research and Development Center of Microbial Fharmaceutical Application Technology， School of Chemical Engineering， Shijiazhuang University， Shijiazhuang 050035， Hebei， China
|
| Abstract: |
| β-nicotinamide mononucleotide（NMN） is the key intermediate of coenzyme I—NAD+ （nicotinamide adenine dinucleotide）synthesis，and is present in various organisms. NAD+ is widely involved in a variety of reactions in the body and plays a very important role in human health. After taking NMN， the level of NAD+ in the body can be rapidly increased. Research on the biology of NMN has been providing many critical insights into the pathogenesis of age-associated functional decline and diseases over the past several years. Studies have found that NMN has a variety of functions， such as anti-aging， promoting heart and brain health. NMN has become a research hotspot in the fields of health products and raw food materials and its market capacity is growing rapidly. At present， a variety of health products with NMN as the main component have been put on the market. Based on the continuous hot research situation of NMN and the huge market expectation in the future， this paper systematically reviews the research background， mechanism， health care function， global brand products， main chemical and biological synthesis routes of NMN，in order to provide reference for popularizing and promoting the research and application of NMN in the field of human health. |
| Key words: β-nicotinamide mononucleotide（NMN） nicotinamide phosphoribosyl transferase（NAMPT） nicotinamide riboside kinase（NRK） enzymatic synthesis anti-aging |
