| 摘要: |
| 中药材资源是中医药的物质基础，其质量事关临床用药的安全性与有效性，其科学评价是中药产业现代化、标准化以及国际化的前提条件。中药材的性状特征、药效成分以及分子标记为迄今三类质量评价方法的主要依据。近年来，微性状鉴定及仿生识别技术的应用显著提高了基于性状特征评价中药材质量的准确性与客观性；中药指纹图谱、代谢组学技术与化学计量学的应用极大地促进了基于药效成分评价中药材质量的科学性及相应有效成分群的发现；基因组学及蛋白质组学的进展推动了分子标记的挖掘及相应分子鉴定技术的建立。上述方法学进展为中药材质量标准体系的建设和中药材资源的开发利用提供思路与借鉴。 |
| 关键词: 中药材 质量评价 外观性状 药效成分 分子标记 |
| DOI：10.14188/j.ajsh.2020.06.008 |
| 分类号:S567 |
| 基金项目:国家自然科学基金面上项目（81872961）；江苏省镇江市重点研发计划(社会发展)项目(SH2018023)；安徽省高等学校自然科学研究重大项目（KJ2019ZD80）；江苏省大学生实践创新训练计划项目（201910299052Z） |
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| Research progress in quality evaluation methods of Chinese medicinal materials |
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WEN Chongwei1, HUANG Jiaying1, ZHU Ruiling1, TANG Jian2, OUYANG Zhen1
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1.College of Pharmacy， Jiangsu University， Zhenjiang 212013， Jiangsu， China;2.Traditional Chinese Medicine College，Bozhou University， Bozhou 236800， Anhui， China
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| Abstract: |
| Resources of Chinese medicinal materials are the material basis of Chinese medicine. The quality of traditional Chinese medicinal materials （TCMM） has the great influence on its safe and effective clinical applications. Therefore， the scientific evaluation of TCMM becomes a prerequisite for the modernization， standardization and internationalization of traditional Chinese medicine industry. At present， appearance characters， medicinal components and molecular markers of TCMM are the main basis for the quality evaluation. In recent years， the application of techniques based on microscopic identification and bionic identification in the quality evaluation of TCMM has significantly improved the accuracy and objectivity. In addition，the application of the chemical fingerprints and metabolomics techniques has facilitated the analysis of complicated chemical constituents and accurate quality evaluation of TCMM. Moreover， advances of research techniques in genomics and proteomics have promoted the discovery of quality-related DNA and protein molecular markers and the establishment of corresponding molecular identification techniques for quality evaluation of TCMM. This paper aims to summarize these above research progress in order to provide reference for the construction of the quality standard system of TCMM and the development and utilization of Chinese medicinal materials. |
| Key words: Chinese medicinal materials quality evaluation appearance character medicinal component molecular marker |
