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| 摘要: |
| 放线菌素D是人类发现的第一个具有抗肿瘤活性的抗生素,但由于毒性太大,因而被限制用于几种恶性肿瘤治疗。本文概述了天然放线菌素的结构特点,重点介绍了放线菌素生物合成过程:犬尿氨酸途径,非核糖体肽合成途径和吩恶嗪酮发色团形成。对放线菌素生物合成途径的探索非常有利于开发新颖的低毒性的结构类似物。 |
| 关键词: 放线菌素 生物合成 犬尿氨酸途径 非核糖体肽合成途径 吩恶嗪酮 |
| DOI： |
| 分类号:R93 |
| 基金项目: |
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| Progress on Biosynthesis of Actinomycins |
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| Abstract: |
| Actinomycin D is the first discovery of antibiotics with strong antineoplastic activity. Owing to extreme toxicity, its clinical application as chemotherapeutics has been limited to the treatment of malignant tumors. This review outlines the structural characteristics of natural actinomycins and focuses on actinomycin biosynthesis including kynurenine pathway,nonribosomal petide synthesis pathway and phenoxazone chromophore formation. Progress on the biosynthesis of actinomycins is conducive to the development of new low toxicity structural analogs of actinomycins. |
| Key words: actinomycin biosynthesis kynurenine pathway nonribosomal petide synthetase phenoxazone |
