| 摘要: |
| 以林肯链霉菌9502(Streptomyces lincolnensis 9502)为出发菌株,进行NTG诱变处理,并用高效的琼脂块培养法对菌株进行筛选,得到产林肯霉素相对效价提高35.4%的变异株9502-7.对9502-7菌株孢子采用紫外线处理,得到变异高产菌株9502-7-12,其相对效价较出发菌株提高50%以上. |
| 关键词: 林肯链霉菌 林肯霉素 NTG诱变 紫外诱变 |
| DOI： |
| 分类号:Q93 |
| 基金项目: |
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| Compound Mutagenesis and Screening of High Productivity Strains of Lincomycin |
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| Abstract: |
| Streptomyces lincolnensis 9502,the starting strain in the experiment,was treated with NTG and mutant 9502-7 was screened by efficient agar piece cultural method.The mutant showed lincomycin-producing ability 35.4% higher than the starting strain.Then by treating the spores of mutant 9502-7 with UV,a strain of 9502-7-12 was obtained,whose titer was increased 50% more than the strain 9502.. |
| Key words: Streptomyces lincolnensis lincomycin NTG mutagenesis UV mutagenesis. |
