| 摘要: |
| 探讨补充L-精氨酸对高温应激小鼠免疫功能的影响,结果显示:1.高温应激后各项免疫指标均有显著下降,其中2～8 h免疫功能受到最大损害;2.补充适量L-精氨酸可减轻小鼠胸膜和脾脏急性萎缩;3.补充L-精氨酸后淋巴细胞增殖活性、IL-2浓度和IL-2R 的表达与对照组比较有显著上升.4.补充L-精氨酸组的活化胸腺细胞[Ca2+]显著高于给水对照组,说明L-精氨酸对热应激小鼠胸腺具有保护作用.实验观察到当补充L-精氨酸浓度达到1.5 mg/g.bw 时,四项指标效果最好,揭示该浓度可最大程度缓解热应激对小鼠免疫功能的抑制. |
| 关键词: L-精氨酸 高温应激 小鼠 免疫指标 |
| DOI： |
| 分类号:R392.1 |
| 基金项目: |
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| Effect of L-Arginine on Mouse Immunity under High Temperature Stress |
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| Abstract: |
| The effect of L-arginine on mouse immunity under high temperature stress was studied. The immune index decreased significantly and reached the lowest at the time of 2-8 hours after heat stress,and mouse immunity was damaged. L-arginine supplementation of appropriate dose could remit the acute atrophy of thymus and spleen tissue caused by heat. After the L-arginine supplementation,lymphocyte proliferation,IL-2 concentration and IL-2Rexpression raised in the test group with room temperature. Ca 2+ in activated thymocytes of the test group with L-arginine supplementation was significantly higher than that of the group with water supplementation. Results indicated that L-arginine supplementation at 1.5 mg/g·bw could remit repression of heat stress on mouse immunity. |
| Key words: L-arginine heat stress mouse immunity |
