| 摘要: |
| 使用D-半乳糖建立衰老大鼠模型组与同龄、同饲的正常对照组大鼠的某些脑区游离氨基酸(FAA)水平的比较发现:(1)衰老模型组的海马、纹状体以及皮层等脑区中谷氨酸(Glu)、天门冬氨酸(Asp)水平明显降低;(2)γ-氨基丁酸(GABA)水平在衰老模型组大鼠的海马,纹状体以及小脑等脑区中明显升高;(3)衰老模型组的皮层、小脑、海马、纹状体等脑区的牛磺酸(Tau)水平明显下降.以此探讨动物衰老与脑区游离氨基酸水平的关系. |
| 关键词: 衰老 脑区 游离氨基酸 |
| DOI： |
| 分类号:Q419 |
| 基金项目: |
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| Changes of Free Amino Acid Levels in Different Brain Regions of Aging Rats |
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| Abstract: |
| Wistar's rats were injected with D-galactose to construct a aging animal model. Then the free amino acid levels in certain brain regions of the aging model were compared with control group. The results showed: (1)Glu and Asp levels of hippocampus(hipp.), striatum(str.) and cortex(cort.) decreased obviously in aging model; (2)GABA level of hippocampus, striatum and cerebellum(cerebell.) regions increased apparently in aging model; (3)taurine level of cerebellum, hippocampus, striatum and cortex decreased obviously in aging model group. |
| Key words: aging brain region free amino acid |
