| 摘要: |
| 报道了重组α1b干扰素软膏对豚鼠皮肤单纯疱疹病毒感染 的局部治疗的效果。目的是在疱疹病毒感染的动物模型上证实α1b干扰素软膏的治疗作用，为该药的临床应用提供临床前药效学资料。结果表明α1b干扰素软膏对疱疹病毒的 皮肤感染具有缩短病程，促进结痂及痊愈的效果，可作为一种外用抗疱疹病毒药物应用于临床。 |
| 关键词: 基因工程 α1b干扰素软膏 单纯疱疹病毒 |
| DOI： |
| 分类号:Q784 |
| 基金项目: |
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| Inhibition Efficacy of the Paste Containing Recombinant IFN-α1b on the Skin Infections of HSV-I to Guinea Pigs |
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| Abstract: |
| The paste containing recombinant IFN-α1b (rIFN-α1 b) and appropriate auxiliary was tested to treat Guinea Pigs infected by HSV-I. The aim was to demonstrate the cureing function of the rIFN-α1b paste on HSV -I infected animal model and to provide information on proclinical pharmacodynam ics for its clinical application. The results showed that the paste had signific ant therapentic effect that shortened the course of disease, alleviated the sym ptoms and promoted scab formation. recovery. This suggested that it could be us ed as a topical anti-herpetic agents in clinic. |
| Key words: Recombinant α 1b-IFN HSV. |
