| 摘要: |
| 以苯胺类化合物为起始原料，经重氮化、丙烯酸加成、氨解 等反应合成了7种消旋苯环取代苯丙氨酸类氨基酸，并采用α-糜蛋白酶或枯草杆菌蛋白酶 对所有氨基酸进行了拆分，其结构分别通过红外光谱、核磁共振、元素分析、熔点、旋光等 分析得到确证。该法可以较大规模合成此类氨基酸。 |
| 关键词: 非天然氨基酸 合成 拆分 |
| DOI： |
| 分类号:O629.7 |
| 基金项目: |
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| Synthesis and Resolution of Ring-substituted phenylalanines |
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| Abstract: |
| Seven racemic aromatic ring modified phenylalanines wer e sy nthesized using aniline derivatives as raw materials. The amino acids were resol ved with α--chymotrypsin or subtilisin. D-and L-amino acids were separ ated from each other. The chemical structures of the amino acids were characteri zed by IR, 1 HNMR, EA and optical rotation. The procedure mentioned here coul d be scaled up for producing the amino acids. |
| Key words: unusual amino acid synthsize resolution |
