| 摘要: |
| 以Nε-苄氧羰基保护的L-赖氨酸(L-Lys(Z)-OH)为原料,经过混合酸酐活化,与重氮甲烷反应合成重氮酮,再经Wolff重排,合成了具有光学活性的L-7-(N-苄氧羰基)氨基-3-(N-叔丁氧羰基)氨基-正庚酸. |
| 关键词: 合成 重氮酮 L-7-(N-苄氧羰基)氨基-3-(N-叔丁氧羰基)氨基-正庚酸 Arndt-Eistert反应 Wolff重排 |
| DOI： |
| 分类号:Q591.2 |
| 基金项目: |
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| Synthesis of L-7-(Benzyloxycarbonyl amino)-3-(tert-Butoxy Carbonyl amino)-Enanthic Acid |
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| Abstract: |
| Optically active (L) 7 (Benzyloxycarbonyl amino) 3 (tert butoxy carbonyl amino) enanthic acid, were Synthezed from (L) ε Benzyloxycarbonyl protected lysine using the methodology introduced by Amdt Eistert with mixed anhydride as a key step and following diazoketone and Wolff rearrangment. |
| Key words: Synthesis Diazoketone (L) 7 (Benzyloxycarbonyl amino) 3 (tert butoxy carbonyl amino) enanthic acid Arndt Eistert reaction Wolff rearrangement |
